Methods for modulating immune responses

摘要

The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents.

主权项

1. A method for down-regulating the immune response a subject's peripheral blood mononuclear cells (PBMCs) exhibit when they are exposed to a non-self antigen on a transplant, the method comprising the step of simultaneously administering to the subject a purified population of CD117-negative Amnion-derived Multipotent Progenitor (AMP) cells and the transplant such that the AMP cells down-regulate the immune response exhibited by the subject's PBMCs upon exposure to the non-self antigen on the transplant.