| 发明名称 |
Glucosylceramide synthase inhibitors |
| 摘要 |
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer. |
| 申请公布号 |
US9139580(B2) |
申请公布日期 |
2015.09.22 |
| 申请号 |
US201314030725 |
申请日期 |
2013.09.18 |
| 申请人 |
Genzyme Corporation |
发明人 |
Bourque Elyse;Hirth Bradford;Sklerj Renato;Makino Elina;Morshed Fazeela;Li Lingyun;Mason Paul;Leonard John P.;Lillie James;Liu Hanlan;Cromwell Mary A.;Wang Bing;O'Shea Thomas |
| 分类号 |
A01N43/90;A61K31/44;C07D453/02;A61K38/47;A61K31/439;A61K31/454;C07D453/00 |
主分类号 |
A01N43/90 |
| 代理机构 |
|
代理人 |
Tousignant Jennifer D. |
| 主权项 |
1. A compound represented by the following structural formula, or a pharmaceutically acceptable salt thereof. |
| 地址 |
Cambridge MA US |
