Platinum compounds for treating cell proliferative diseases, preparation method and use thereof

摘要

Disclosed are a class of platinum compounds with a leaving group of malonic acid derivatives containing amino and alkylamino, their pharmaceutically acceptable salts, their preparation methods and pharmaceutical composites comprising them. Disclosed also are for the uses of the compounds in the treatment of cell proliferative diseases, particularly for the treatment of cancers. The present platinum compounds have high water solubility and low toxicity.

主权项

1. A compound of formula A, or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof,wherein:
R1 and R2 are the same or different, selected from hydrogen, alkyl, naphthenic base, alkoxy alkyl, alkyl amino alkyl, heterocycle, alkenyl, alkynyl; wherein hydrocarbyl, alkoxy alkyl, alkyl amino alkyl and heterocycle are unsubstituted or optionally substituted, provided that R1 and R2 do not contain an unsaturated bond, or R1 and/or R2 contains an unsaturated bond, while the atom of the unsaturated bond cannot be directly connected with a nitrogen atom; R3 is selected from alkyl, naphthenic base and —R31—O—R32—; R31 and R32 are independently selected from bond or alkyl; R31 is connected with nitrogen atom; provided that R31 does not contain an unsaturated bond, or R31 contains an unsaturated bond, while the atom of the unsaturated bond cannot be directly connected with the nitrogen atom; wherein the alkyl and naphthenic base are unsubstituted or optionally substituted; R4 and R5 are the same or different, selected from: hydrogen, hydroxyl, alkyl, naphthenic base, alkoxy, alkoxy alkyl, heterocycle, alkenyl, alkynyl; wherein alkyl, alkenyl, alkynyl, naphthenic base, alkoxy alkyl, alkyl amino alkyl and heterocycle are unsubstituted or optionally substituted; R4, R5 and the atoms they connected maybe together form a closed ring; the said ring may be quaternary, pentabasic, hexahydric, heptabasic or octatomic ring; said ring is optionally condensed with other rings and optionally substituted.