Method for treatment of constipation-predominant irritable bowel syndrome

摘要

The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in an alternative embodiment also provides methods for treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome.

主权项

1. A method of treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome (a-IBS), comprising administering to a patient in need of such treatment, an amount of an extract or latex isolated from Croton spp. or Calophyllum spp. effective to treat a-IBS, wherein said amount is bioequivalent to an orally administered dose of about 50 mg per day to about 500 mg per day of crofelemer.