Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias

摘要

Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.

主权项

1. A method to interfere with an acute lymphoblastic leukemia (ALL) response signaling pathway in at least one leukemic cell producing an ALL1/AF9 chimeric fusion protein, wherein the method comprises:
administering, to at least one K562 leukemic cell, 5-iodotubericidin and an ALL1/AF9-specific siRNA consisting of “SEMj” which suppresses expression of an ALL1/AF9 chimeric fusion protein, thereby interfering with an acute lymphoblastic leukemia (ALL) response signaling pathway.