| 发明名称 | Multi-component L2 vaccine for prevention of human papilloma virus infection | ||
| 摘要 | Embodiments of the invention are directed to methods and compositions for generating an antibody response against HPV epitopes using multi-component vaccines. One such multi-component vaccine requires a T cell helper component and a toll-like receptor (TLR) agonist. In one embodiment, the inventors described a lipopeptide composition comprising an HPV L2 epitope. | ||
| 申请公布号 | US9138470(B2) | 申请公布日期 | 2015.09.22 |
| 申请号 | US200812740873 | 申请日期 | 2008.11.03 |
| 申请人 | The Johns Hopkins University | 发明人 | Roden Richard B. S.;Gambhira Ratish;Alphs Hannah H. |
| 分类号 | A61K39/12;C07K19/00;C07K16/08;A61P37/04;A61P31/20;C07K14/005;C12N7/00;A61K39/00 | 主分类号 | A61K39/12 |
| 代理机构 | Venable LLP | 代理人 | Venable LLP ;Kirchanski Stefan J.;Lopez Miguel A. |
| 主权项 | 1. A multi-component human papillomavirus (PV) L2 composition comprising one or more constructs comprising: (a) a peptide component comprising a Human Papillomavirus L2 (HPV-L2) peptide coupled to a T helper cell (Th) epitope; and (b) a lipid Toll Like Receptor (TLR) agonist, wherein the multi-component human papillomavirus (PV) L2 composition induces a humoral immune response, and wherein the TLR agonist is simultaneously linked to both the HPV-L2 peptide and the Th epitope forming a junction therebetween. | ||
| 地址 | Baltimore MD US | ||