发明名称 |
Sustained-release nanoparticle compositions and methods using the same |
摘要 |
The present invention is a composition composed of a therapeutic agent encapsulated in a copolymer of an N-alkylacrylamide, a vinyl monomer, and a polyethylene glycol (PEG) conjugate and a method for using the same in the treatment or prevention of a disease or condition. |
申请公布号 |
US9138416(B2) |
申请公布日期 |
2015.09.22 |
申请号 |
US201314064698 |
申请日期 |
2013.10.28 |
申请人 |
Board of Regents of the University of Nebraska by and behalf of the University of Nebraska Medical Center |
发明人 |
Labhasetwar Vinod D.;Sahoo Sanjeeb K.;Reddy Maram K. |
分类号 |
A61K9/14;A61K9/48;A61K9/00;A61K9/51;A61K31/00;A61K31/436;B82Y5/00 |
主分类号 |
A61K9/14 |
代理机构 |
Dann, Dorfman, Herrell and Skillman, P.C. |
代理人 |
Hagan Patrick J.;Dann, Dorfman, Herrell and Skillman, P.C. |
主权项 |
1. A sustained-release composition in nanoparticle form consisting essentially of a therapeutic agent and a cross-linked copolymer of an N-alkylacrylamide selected from the group consisting of N-methyl-N-n-propylacrylamide, N-methyl-N-isopropylacrylamide, N-propylmethacrylamide, N-isopropylacrylamide, N—N-diethylacrylamide, N-isopropylmethacrylamide, N-cyclopropylacrylamide, N-ethylmethacrylamide, N-methyl-N-ethylacrylamide, N-cyclopropylmethacrylamide and N-ethylacrylamide, a vinyl monomer selected from the group consisting of a vinyl alcohol, a vinyl ether, a vinyl ester, vinyl pyrrolidone and a combination of said vinyl monomers, and PEGylated maleic acid conjugate, wherein the weight per weight ratio of the N-alkylacrylamide, vinyl monomer and PEGylated maleic acid conjugate is 70-90:9-20:1-10, said therapeutic agent being encapsulated in said copolymer in an amount from 3% to 10% based on said nanoparticle weight, and said composition being effective to release said therapeutic agent for at least 2 to 3 weeks. |
地址 |
Omaha NE US |