发明名称 |
Fibrinogen immune complexes to diagnose and guide therapy in rheumatoid arthritis |
摘要 |
Compositions and methods are provided for prognostic classification of rheumatoid arthritis disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. |
申请公布号 |
US9140701(B2) |
申请公布日期 |
2015.09.22 |
申请号 |
US201012806081 |
申请日期 |
2010.08.04 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
Robinson William H.;Ho Peggy Pui-Kay;Zhao Xiaoyan;Steinman Lawrence M. |
分类号 |
G01N33/53;G01N33/566;G01N33/564;G01N33/50 |
主分类号 |
G01N33/53 |
代理机构 |
Bozicevic, Field & Francis LLP |
代理人 |
Bozicevic, Field & Francis LLP ;Sherwood Pamela J. |
主权项 |
1. A method for the prognosis of the severity of rheumatoid arthritis in a human individual, the method comprising:
detecting circulating immune complexes containing citrullinated fibrinogen and immunoglobulin in a sample of blood or derivative therefrom obtained from the individual; analyzing the fibrinogen immune complex content in said sample relative to a normal control by contacting the blood sample with C1q protein; contacting immune complexes bound to the C1q protein with an agent that selectively binds to fibrinogen; detecting the presence of a fibrinogen containing immune complexes; wherein the presence of said fibrinogen containing immune complexes, compared to a control sample, is indicative of positive binding; and providing an assessment of prognosis for said individual, where the presence of the immune complexes containing fibrinogen is indicative of a more severe disease prognosis. |
地址 |
Palo Alto CA US |