| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to simultaneous, separate or sequential administration of a combination, comprising at least one sigma ligand of formula,at least one opioid or opiate compound selected from the group consisting of morphine, tramadol, sufentanil, remifentanil, fentanyl, tapentadol, oxycodone, buprenorphine for use in the prevention and/or treatment of pain developed as a consequence of surgery. In formula (I) Ris selected from the group formed by hydrogen, unsubstituted C-Calkyl and -COR; Ris selected from the group formed by hydrogen, unsubstituted C-Calkyl and unsubstituted phenyl; Rand Rare independently selected from the group formed by hydrogen, unsubstituted C-Calkyl, unsubstituted phenyl, unsubstituted C-Caryl C-Calkyl, -ORand halogen; or together they form an optionally substituted fused ring system; n is selected from 2, 3 or 4; Ris an unsubstituted C-Calkyl; Rand Rare given in the claims.EFFECT: invention also refers to the sigma ligand of formula (I) for use in potentiating the analgesic effects of an opioid or opiate.10 cl, 12 dwg, 2 ex |
