| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to medicine and represents bioresorbable polymer cell matrix for tissue engineering. Matrix contains frame-carrier for cell cultures and biological agents. Frame is made assemblable from N oriented with respect to each other two-dimensional matrices with N?1 with possibility of their fixation in pile after inoculation with cells for tissue engineering. Each of two-dimensional matrices is formed by means of lithography in form of polymer film with surface arrays of micro- and/or nanoobjects. Arrays are characterised by individual architecture, consistency and interrelationship of location in architecture of micro- and/or nanoobjects, with possibility of specifying structure of bone tissue which is to be formed, account of its biological functions, with possibility to provide mechanical support, control of processes of cell differentiation and proliferation.EFFECT: control of process of tissue regeneration, process localisation and direction, increase of tissue regeneration efficiency, achievement of reproducibility in processes and results of tissue regeneration.10 cl, 19 dwg |
