| 摘要 |
FIELD: biotechnologies.SUBSTANCE: invention relates to the method of producing of penta-1,2,3,4,6-(2-glycidyl oxy ethoxy)-ethyl ether of glucose and to its use in the composition for chemical linking of collagen-containing endoprostheses of biological origin that can be used in medicine. In the offered method penta-1,2,3,4,6-(2-glycidyl oxy ethoxy)-ethyl ether of glucose is produced by reaction of D-glucose with 2-{ 2-([vinyloxy]etoxy)methyl}-oxirane in the solvent 1,4-dioxane, 1,2-dimethoxyethane or tetrahydrofuran at 80-96°C in presence of trifluoroacetic acid. The method allows to increase selectivity of formation of penta-1,2,3,4,6-(2-)-ethyl ether of glucose. The offered composition includes penta-1,2,3,4,6-(2-glycidyl oxy ethoxy)-ethyl ether of glucose in water buffer solutions (pH 5.0-8.0) with adding of isoosmolar compounds providing osmolarity of composition in the range 260-310 mosm/l.EFFECT: possibility of efficient linking of collagen-containing biomaterials.5 cl, 10 ex |
