COMPOSITIONS AND THEIR USE IN TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS

摘要

The invention features compositions for treating or preventing a neoplasia. More specifically, the invention provides thienotriazolodiazepine compounds for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).