发明名称 |
COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION ATOH1 |
摘要 |
This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g. a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation. |
申请公布号 |
HK1155652(A1) |
申请公布日期 |
2015.09.18 |
申请号 |
HK20110109951 |
申请日期 |
2011.09.21 |
申请人 |
MASSACHUSETTS EYE & EAR INFIRMARY;THE BRIGHAM AND WOMENS HOSPITAL INC. |
发明人 |
EDGE, ALBERT;SEYB, KATHLEEN;GLICKSMAN, MARCIE;QIAO, LIXIN;CUNY, GREGORY D.;JEON, SANG-JUN |
分类号 |
A61K;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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