MOLECULAR SIGNATURE FOR AGGRESSIVE SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK

摘要

The present invention encompasses methods of classifying HNSCC tumors, such as OSCC tumors, as aggressive or, alternatively, indolent.

主权项

1. A method for determining the aggressiveness of head and neck squamous cell carcinoma (HNSCC) in a subject, the method comprising:
(a) providing a test sample from a subject known to have HNSCC; (b) determining the nucleic acid expression levels in the test sample of at least 10-nucleic acids selected from Table A:TABLE ABEX2TRIM39E2F4PKIADSG3IL18RAPPIP5K1ARGL2HOXB7P4HA2DCBLD2CYR61IGF2BP1RAB38CASP1VDRMUC1GSTO2SYTL4 STXBP1EOMESSART1TACSTD2P2RY1NKX2-3INSM1PDGFAOLFML2BMEIS1STARD13TIMP2PPFIBP2UNC13BMLLT11CAPN5TIAM1TDRKHDISP1SIRT5AP1M1FNTALYNX1TRAFD1STARD5FOXA1RAB40CCOLGALT1SLC6A9DMKNSYTL1ME2MTMR9GSTA4PGPEP1PLA2G15EPHX1IVLFMNL1BBS4AQP3ANKRD1ADPRHL2RAB3DPI4KAGSPT2CACNB2TAF13WNT4KLF2MAGEE1FARP1DHX38LPAR1CDH2LASP1ASS1GPX2CELF2PCOLCE2SLPIMGRN1CRKEPHA1IMPA2PCYT1BHRFXYD3TNNC1WRBFAHD2AECM1CBR3 (c) comparing the expression levels of each nucleic acid in (b) to the corresponding reference expression levels of such nucleic acids, wherein differentially expressed levels in the test sample compared to the reference expression levels indicates aggressive HNSCC.