| 发明名称 |
COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION IN CONE CELLS |
| 摘要 |
The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells. |
| 申请公布号 |
US2015259395(A1) |
申请公布日期 |
2015.09.17 |
| 申请号 |
US201514660657 |
申请日期 |
2015.03.17 |
| 申请人 |
Avalanche Biotechnologies, Inc. ;University of Washington |
发明人 |
Chalberg Thomas W.;Neitz Jay;Neitz Maureen |
| 分类号 |
C07K14/705;C12N7/00;C12N15/86 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polynucleotide cassette for enhanced expression of a transgene in cone cells of a mammalian retina, comprising
(a) a promoter region, wherein the promoter region is specific for retinal cone cells; (b) a coding sequence operatively linked to the promoter region; and (c) a polyadenylation site. |
| 地址 |
Menlo Park CA US |
