| 发明名称 |
METHOD FOR PREVENTING NEOPLASTIC TRANSFORMATION BY INHIBITION OF RETINOBLASTOMA PROTEIN INACTIVATION |
| 摘要 |
A method for preventing neoplastic transformation by inhibition of cell cycle progression into S phase by preventing the inactivation of Retinoblastoma protein (Rb). |
| 申请公布号 |
US2015259384(A1) |
申请公布日期 |
2015.09.17 |
| 申请号 |
US201314394203 |
申请日期 |
2013.04.12 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Burke Jason;Rubin Seth |
| 分类号 |
C07K7/64;C07K7/06 |
主分类号 |
C07K7/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the reduction of cell proliferation by inhibition of cell cycle progression into S phase by stabilizing the Rb-E2F complex, the method comprising contacting the cell with a synthetic molecular inhibitor of RbN-pocket association, whereby the molecular inhibitor molecule inhibits the interaction between the Rb pocket and Rb N-terminal domain. |
| 地址 |
OAKLAND CA US |
