| 主权项 |
1. A compound of Formula (I)wherein
L is a bond, —CH2—, —SO2—, —CH2—SO2—, —SO2—CH2—, —SO2—NR—, —SO2—NR—CH2—, —CH2—SO2—NR—, —NR—, —NR—SO2—, —S—, —S—CH2—, —CH2—S—, —C(═O)—, —O—, —O—CH2—, —NR—C(═O)—, or —C(═O)—NR—, wherein R is H, C1-2alkyl, C1-2alkyl-OH or cyclopropyl; R1 is H, halo, methyl, CF3, —O—CF3, or —O—CH3; R2 is H, cyano, halo, 2-(trimethylsilyl)ethoxy, phenyl, C1-6alkyl, heteroaryl, heterocyclyl, C3-9cycloalkyl, provided R2 is not H if L is a bond, and wherein said phenyl, C1-6alkyl, heteroaryl, heterocyclyl or C3-9cycloalkyl is optionally and independently substituted selected from the group consisting of: methyl, ethyl, oxo, fluoro, hydroxyl, cyano, amino, methoxy, tert-butoxy, acetyl, cyclopropyl, cyclobutyl, cyclohexyl, phenyl, azetidin-1-yl, azetidin-3-yl, pyrrolidin-1-yl, 2,4-dihydro-3H-1,2,4-triazol-3-one-4-yl, 1H-imidazol-4-yl, pyrazin-2-yl, pyrimidin-2-yl, 1,3-oxazolidin-2-one-5-yl, N-benzamide, 4-methylpiperazin-1-yl, morpholin-4-yl, CF3, —SO2—CH3, —C(═O)-cyclopropyl, —NHCH3, —N(CH3)2, —NHAc, —NHCO2t-Bu, —CH2—NH2, —C(═O)—NH2, —C(═O)—N(ethyl)2, —NH—C(═O)—NH2, —NH—C(═O)—CH3, —C(═O)—(C1-C4alkyl), —C(═O)—OH, —C(═O)—NH(C1-C4alkyl)-(CH2)n—OH, and —(CH2)n—CN, wherein n is 1 or 2; V is CH, CR′, or N, wherein R′ is methyl or F; W is CR″ or N, wherein R″ is H, F, hydroxyl, amino, CH3 or —O—CH3; ring A is selected from the group consisting of: R3 is H, F, methyl, or —O—CH3; R3′ is H or F; R4 is H, methyl, cyano, amino, halo, —COOH, or —O—CH3; R5 is H, methyl, cyano, or —CF3; R6 is H, cyano, amino, halo, or —CF3; and R7 is halo, amino, —CONH2, cyano, —O—CH3, —CF3, or —COO-ethyl;or a pharmaceutically acceptable salt thereof. |
