| 发明名称 |
PROCESS TO PRODUCE ATORVASTATIN INTERMEDIATES |
| 摘要 |
The invention provides a process for the production of 1 a compound of formula (I), said process comprising reacting a compound of formula (II), with a compound of formula (III), wherein R1 and R2 may be the same or different and are selected from H; a C1-C6 alkyl which may be straight or branched, substituted or unsubstituted; or R1 and R2 together represent an alkylidene group of the formula CRaRb wherein Ra and Rb may be the same or different and are selected from an alkyl group having between 1 and 6 atoms, and wherein R3 represents a C1-C6 alkyl group, wherein the reaction is carried out in the presence of a base. Using a base may advantageously allow a lower temperature and/or may result in a higher yield. Also, a phase separation step may be omitted.; |
| 申请公布号 |
US2015259285(A1) |
申请公布日期 |
2015.09.17 |
| 申请号 |
US201314428153 |
申请日期 |
2013.09.12 |
| 申请人 |
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. |
发明人 |
De Lange Ben;Heemskerk Dennis;Elsenberg Henricus Leonardus Marie |
| 分类号 |
C07D207/34 |
主分类号 |
C07D207/34 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Process for the production of a compound of formula I,said process comprising reacting a compound of formula IIwith a compound of formula IIIwherein R1 and R2 may be the same or different and are selected from H; a C1-C6 alkyl which may be straight or branched, substituted or unsubstituted; or R1 and R2 together represent an alkylidene group of the formula CRaRb wherein Ra and Rb may be the same or different and are selected from an alkyl group having between 1 and 6 atoms, and wherein R3 represents a C1-C6 alkyl group, wherein said reaction is carried out in the presence of a base. |
| 地址 |
Delft NL |
