Allograft tolerance induction

摘要

A method inducing chimerism and allograft tolerance by co-infusion of stein/progenitor-like cells and donor cells, wherein the donor cells can be bone marrow cells. The method also comprises the conditioning comprising depletion of CD4+ and CD8+ T-cells and administration of low doses of anti-neoplastic drugs. The inventive method comprises an aspect wherein allograft tolerance is induced without systemically suppressing the immune system.

主权项

1. A transplantation method comprising inducing allograft tolerance and chimerism by administering to a host one or more doses of human stem/progenitor-like cells and allogeneic donor cells, wherein said allogneic donor cells are, unprocessed bone marrow, low density bone marrow cells or side population stem cells, to a host, depleting of CD4+ and CD8+ cells and administering a nonmycloablative antineoplastic agent.