MICROFLUIDIC DEVICES FOR THE RAPID DETECTION OF ANALYTES

摘要

Provided herein are paper-based microfluidic devices that can be configured to induce fast fluid flow through a hollow microfluidic channel under low applied pressure. The microfluidic devices can comprise a fluid inlet, a fluid outlet, and a hollow channel fluidly connecting the fluid inlet and the fluid outlet, so as to form a fluid flow path from the fluid inlet to the fluid outlet. The hollow channel can comprise a fluid flow path defined by a floor, two or more side walls, and optionally a ceiling. One or more of the interior surfaces of the hollow channel can comprise a hydrophilic material. The hydrophilic material can drive fluid flow through the hollow channel, allowing for fast fluid flow through the hollow microfluidic channel under low applied pressure. The devices are well suited for use in numerous sensing applications, for example, quantitative, low limit-of-detection, and/or point-of-care paper analytical devices.