发明名称 |
Modified caspase polypeptides and uses thereof |
摘要 |
The technology relates in part to compositions comprising modified caspase-9 polypeptides, compositions comprising nucleic acids coding for modified caspase-9 polypeptides, chimeric modified caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified caspase-9 protein, with reduced basal activity in the absence of the inducer. |
申请公布号 |
AU2014249417(A1) |
申请公布日期 |
2015.09.17 |
申请号 |
AU20140249417 |
申请日期 |
2014.03.07 |
申请人 |
BELLICUM PHARMACEUTICALS, INC. |
发明人 |
SPENCER, DAVID;CHANG, WEI-CHUN |
分类号 |
A01N65/00;A61K31/4545;A61K35/14;C12N5/00;C12N9/64;C12P21/00 |
主分类号 |
A01N65/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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