DETERMINING AGE RANGES OF SKIN SAMPLES

摘要

The present invention provides methods for characterizing a skin sample of a subject as belonging to an age range by analyzing nucleic acid or protein molecules obtained from the subject. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample and compare them with a known skin age index. Therapeutic and cosmetic formulations are also provided herein.

主权项

1. A method for determining the age range of a skin sample of a subject comprising
a) providing a skin sample of the subject comprising nucleic acids expressed by genes in a classifier comprising at least one young gene and at least one old gene; wherein the skin sample is obtained by a non-invasive technique; and b) determining expression levels of the nucleic acids in the skin sample by application of at least one detectably labeled probe that hybridizes to one or more of the nucleic acids; whereby the comparison of expression levels of the nucleic acids in the skin sample to expression levels of the nucleic acids in one or more reference skin samples of known age range is indicative of the age range of the skin sample.