Ultrasonic Analyte Concentration and Application in Flow Cytometry

摘要

The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

主权项

1. A method, comprising:
applying an acoustic radiation pressure to a population of particles in a flowing fluid disposed within a tube so as to concentrate at least some of the population of particles; illuminating at least some of the concentrated particles in an interrogation volume within the tube as the particles transit an interrogation volume at a core velocity of less than about 1 m/s.