发明名称 |
LONG ACTING TRAIL RECEPTOR AGONISTS FOR TREATMENT OF AUTOIMMUNE DISEASES |
摘要 |
Methods of treating an autoimmune disease such as rheumatoid arthritis, methods of increasing apoptosis of pro-inflammatory immune cells or synoviocytes, methods of increasing the quantity of the anti-inflammatory regulatory T cells, and methods of slowing the progression of inflammation in a subject include systemically administering to the subject a pharmaceutical composition including an effective amount of a TRAIL- conjugate. Preferably, the TRAIL-conjugate is effective for at least 3 days, more preferably at least 7 days, without being part of a nanocomplex that modulates the circulation half-life or release kinetics of the TRAIL- conjugate. Combination therapies including administering a second active agent, most preferably a TNF-a inhibitor, as well as pharmaceutical composition dosage units including a TRAIL-conjugate and a TNF-a inhibitor in an effective amount for a single once weekly dose for treatment of rheumatoid arthritis are also provided. |
申请公布号 |
WO2015138638(A1) |
申请公布日期 |
2015.09.17 |
申请号 |
WO2015US20015 |
申请日期 |
2015.03.11 |
申请人 |
THERALY PHARMACEUTICALS, INC. |
发明人 |
LEE, KENG, CHOON;EOM, HA, NA |
分类号 |
A61K45/06;A61K38/17;A61K39/395;A61K47/48;A61P19/02;A61P29/00;C12N15/62 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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