发明名称 |
METHODS FOR ACUTE AND LONG-TERM TREATMENT OF ALCOHOL DEPENDENCE USING IBOGAINE |
摘要 |
This invention is directed to a method of treating alcohol dependence, including acute and post-acute withdrawal symptoms, comprising treating an alcohol dependent patient with ibogaine, ibogaine derivative, or pharmaceutically acceptable salt and/or solvate thereof at a dosage that provides an average serum concentration of about 50 ng/mL to about 850 ng/mL under conditions where the QT interval prolongation does not exceed about 50 milliseconds. |
申请公布号 |
US2015258110(A1) |
申请公布日期 |
2015.09.17 |
申请号 |
US201514635797 |
申请日期 |
2015.03.02 |
申请人 |
DEMERX, INC. |
发明人 |
Maillet Emeline;Friedhoff Lawrence |
分类号 |
A61K31/55 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
1. A method for treating alcohol dependence in a human patient suffering therefrom, comprising administering to the patient a dosage of ibogaine, ibogaine derivative, or pharmaceutically acceptable salt and/or solvate thereof that provides an average serum concentration of about 50 ng/mL to about 500 ng/mL, said concentration being sufficient to ameliorate said dependence while maintaining a QT interval of less than about 500 ms during said treatment. |
地址 |
Fort Lauderdale FL US |