发明名称 |
NOVEL KINASE INHIBITORS |
摘要 |
The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.; |
申请公布号 |
US2015259340(A1) |
申请公布日期 |
2015.09.17 |
申请号 |
US201314436152 |
申请日期 |
2013.10.18 |
申请人 |
ORIGENIS GMBH |
发明人 |
Almstetter Michael;Thormann Michael;Treml Andreas;Koestler Roland;Yehia Nasser |
分类号 |
C07D471/04 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of formula (I): wherein n is 1, 2, 3 or 4; R1 is an optionally substituted alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or hetero-aralkyl group; and the groups R2 are independently from each other selected from halogen, OH, C1-6 alkyl, C1-6 heteroalkyl or C3-6 cycloalkyl; or a pharmaceutically acceptable salt, ester, solvate or hydrate or a pharmaceutically acceptable formulation thereof. |
地址 |
Martinsried DE |