发明名称 |
RECEPTOR BINDING CONJUGATES |
摘要 |
The present invention relates to a receptor binding conjugate which consists of an antibody, a radionuclide and folate or a folate derivative, wherein or not the conjugate possesses dual binding ability. The present invention also relates to a method and a kit to prepare, as well as a method to use, such conjugates. Furthermore, the use of a conjugate according to the present invention to prepare a pharmaceutical solution is disclosed. |
申请公布号 |
US2015258223(A1) |
申请公布日期 |
2015.09.17 |
申请号 |
US201414571524 |
申请日期 |
2014.12.16 |
申请人 |
Algeta ASA |
发明人 |
LARSEN Roy H.;HENRIKSON Gjermund |
分类号 |
A61K51/10;A61K51/04;C07B59/00;C07K16/30 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
|
主权项 |
1. Receptor binding conjugate, characterized in that it consists of three components; (1) an antibody or antibodies preferably of IgG or IgM class, or fragments or constructs (e.g. minibody) thereof, (2) a radionuclide or a mixture of radionuclides and (3) folate or a folate derivative, wherein or not the conjugate possesses a dual target binding ability. |
地址 |
Oslo NO |