Substituted Pyrimidine Compound and Uses Thereof

摘要

Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY.;;See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.

主权项

1. A substituted pyrimidine compound represented by formula PY:wherein:
R1 is H, halo, cyano, C1-C12alkyl, C3-C12cycloalkyl, haloC1-C12alkyl, cyanoC1-C12alkyl, cyanoC1-C12alkoxy, C2-C12alkenyl, haloC2-C12alkenyl, C2-C12alkynyl, haloC2-C12alkynyl, C1-C12alkoxyC1-C12alkyl, haloC1-C12alkoxyC1-C12alkyl, C1-C12alkoxycarbonylC1-C12alkyl, C1-C12alkylaminocarbonylC1-C12alkyl, or di(C1-C12alkyl)aminocarbonylC1-C12alkyl; R2 is H, halo, cyano, C3-C12cycloalkyl, C1-C12alkoxy, or haloC1-C12alkoxy; R3 and R4, may be the same or different, and are each selected independently from the group consisting of H, halo, OH, amino, C1-C12alkyl, C1-C12alkoxy, C3-C12cycloalkyl, C2-C12alkenyl, C2-C12alkynyl, haloC2-C12alkenyl, haloC2-C12alkynyl, C1-C12alkoxyC1-C12alkyl, unsubstituted or further substituted arylC1-C6alkyl or heteroarylC1-C6alkyl by 1 to 5 following groups: halo, C1-C6alkyl, haloC1-C6alkyl, C1-C6alkoxy, and haloC1-C6alkoxy; or R3, R4 and conjoint carbon can also form a C3-C8 cycle; R5a, R5b, and R5c, may be the same or different, and are each selected independently from the group consisting of H, halo, OH, NO2, cyano, C1-C12alkyl, haloC1-C12alkyl, C3-C12cycloalkyl, C1-C12alkoxy, haloC1-C12alkoxy, C1-C12alkylthio, haloC1-C12alkylthio, C2-C12alkenyl, haloC2-C12alkenyl, C2-C12alkynyl, haloC2-C12alkynyl, C3-C12alkenoxy, haloC3-C12alkenoxy, C3-C12alkynoxy, haloC3-C12alkynoxy, C1-C12alkylsulfinyl, haloC1-C12alkylsulfonyl, haloC1-C12alkylsulfonyl, C1-C12alkylcarbonyl, haloC1-C12alkylcarbonyl, C1-C12alkylcarbonyloxy, C1-C12alkylcarbonylamino, C1-C12alkylsulfonyloxy, C1-C12alkoxycarbonyl, C1-C12alkoxycarbonylC1-C12alkyl, C1-C12alkoxycarbonylamino, C1-C12alkoxyC1-C12alkoxy, and C1-C12alkoxycarbonylC1-C12alkoxy; X1 is N or CR6; X2 is N or CR7; X3 is N or CR8; X4 is N or CR9; X5 is N or CR10; X6 is N or CR11; however, X2, X3, X4, X5, X6 are not simultaneously N; R6, R7, R8, R9, R10, and R11, may be the same or different, and are each selected independently from the group consisting of H, halo, OH, cyano, HO(C═O), amino, NO2, C1-C12alkyl, haloC1-C12alkyl, C1-C12alkoxy, haloC1-C12alkoxy, C3-C12cycloalkyl, C2-C12alkenyl, C2-C12alkynyl, C2-C12alkenoxy, haloC2-C12alkenoxy, C2-C12alkynoxy, haloC2-C12alkynoxy, C1-C12alkylthio, haloC1-C12alkylthio, C1-C12alkoxyC1-C12alkyl, haloC1-C12alkoxyC1-C12alkyl, C1-C12alkylthioC1-C12alkyl, haloC1-C12alkylthioC1-C12alkyl, C1-C12alkylsulfinyl, haloC1-C12alkylsulfinyl, C1-C12alkylsulfonyl, haloC1-C12alkylsulfonyl, C1-C12alkylaminosulfonyl, C1-C12alkylamino, haloC1-C12alkylamino, di(C1-C12alkyl)amino, halodi(C1-C12alkyl)amino, C1-C12alkylcarbonyl, haloC1-C12alkylcarbonyl, C1-C12alkoxycarbonyl, haloC1-C12alkoxycarbonyl, di(C1-C12alkyl)amino(C1-C12alkyl), CONH2, CONHNH2, CON(C1-C12alkyl)NH2, CONHNH(C1-C12alkyl), CONHN(di(C1-C12alkyl)), CONHNHCO(C1-C12alkyl), CONHNHCO2(C1-C12alkyl), CONHNH(phenyl), C1-C12alkylaminocarbonyl, di(C1-C12alkyl)aminocarbonyl, halodi(C1-C12alkyl)aminocarbonyl, C1-C12alkylsulfonylamino, C1-C12alkylsulfonyl(C1-C12alkyl)amino, haloC1-C12alkylsulfonylamino, C1-C12alkoxyamino, C1-C12alkoxycarbonylamino, C1-C12alkoxyaminocarbonyl, cyanoC1-C12alkyl, cyanoC1-C12alkoxy, C1-C12alkoxycarbonylC1-C12alkyl, haloC1-C12alkoxycarbonylC1-C12alkyl, C1-C12alkylaminocarbonylC1-C12alkyl, di(C1-C12alkyl)aminocarbonylC1-C12alkyl, C1-C12alkylthiocarbonylC1-C12alkyl, haloC1-C12alkylthiocarbonylC1-C12alkyl, C1-C12alkylcarbonyloxy, haloC1-C12alkylcarbonyloxy, C1-C12alkoxycarbonyloxy, haloC1-C12alkoxycarbonyloxy, C1-C12alkylaminocarbonyloxy, haloC1-C12alkylaminocarbonyloxy, C1-C12alkylsulfonyloxy, haloC1-C12alkylsulfonyloxy, C1-C12alkoxyC1-C12alkoxy, haloC1-C12alkoxyC1-C12alkoxy, C1-C12alkoxycarbonylC1-C12alkoxy, and haloC1-C12alkoxycarbonylC1-C12alkoxy; W is H, halo, C1-C12alkyl, C1-C12alkoxy, C1-C12alkylthio, or C1-C12alkylsulfonyl; A is O, S, or NR12; B is —CH2—, or —CH2CH2—; and R12 is H, OH, H(C)═O, C1-C12alkyl, haloC1-C12alkyl, C1-C12alkoxy, haloC1-C12alkoxy, C3-C12cycloalkyl, C1-C12alkylthio, C2-C12alkenylthio, C2-C12alkenyl, C2-C12alkynyl, haloC2-C12alkenyl, haloC2-C12alkynyl, C1-C12alkoxyC1-C12alkyl, haloC1-C12alkoxyC1-C12alkyl, C1-C12alkylthioC1-C12alkyl, haloC1-C12alkylthioC1-C12alkyl, C1-C12alkylsulfinyl, haloC1-C12alkylsulfinyl, C1-C12alkylsulfonyl, haloC1-C12alkylsulfonyl, C1-C12alkylaminosulfonyl, di(C1-C12alkyl)aminosulfonyl, C1-C12alkylsulfonylaminocarbonyl, C1-C12alkylcarbonylaminosulfonyl, C3-C12cycloalkyloxycarbonyl, C1-C12alkylcarbonyl, haloC1-C12alkylcarbonyl, C1-C12alkoxycarbonyl, haloC1-C12alkoxycarbonyl, C1-C12alkylcarbonylC1-C12alkyl, C1-C12alkoxycarbonylC1-C12alkyl, C1-C12alkylaminocarbonyl, di(C1-C12alkyl)aminocarbonyl, C2-C12alkenoxycarbonyl, C2-C12alkynoxycarbonyl, C1-C12alkoxyC1-C12alkoxycarbonyl, C1-C12alkylaminothio, di(C1-C12alkyl)aminothio, unsubstituted or further substituted (hetero)arylcarbonylC1-C6alkyl, (hetero)arylcarbonyl, (hetero)aryloxycarbonyl, (hetero)arylC1-C6alkyloxycarbonyl or (hetero)arylC1-C6alkyl by 1 to 5 following groups: halo, NO2, cyano, C1-C6alkyl, haloC1-C6alkyl, C1-C6alkoxy, or haloC1-C6alkoxy; or a salt or complex thereof.