| 摘要 |
Provided are a method for producing a compound (9) useful as a drug for the treatment of diabetes, and a production intermediate thereof. (a) A diester (3) is synthesized by reacting a compound (1) and a compound (2), (b) an ester (4) is synthesized by deprotecting the diester (3) (or an ester (4) is synthesized by reacting a compound (5) and the compound (2)), (c) the ester (4) is converted into an acid halide, (d) the acid halide is reacted with an amidinophenol derivative, and (e) the resulting diester derivative is deprotected under acidic conditions and converted into compound (9) (in the formula, R1 represents a halogen atom, R4 represents a lower alkyl group, R5 represents a lower alkyl group, and R12 represents a hydrogen atom or a halogen atom). |
