BIO-BASED MONOMERS AND POLYMERS

摘要

Described are novel bio-based bioabsorbable/non-absorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful inter alia as medical devices, implantable or otherwise.

主权项

1. A diisocyanate selected from formula (I), (II), or (III): wherein: variable A, the dashed bond, is absent or is a double bond; each R is independently the diacyl residue of a diacid; R′ is absent or each R′ is independently a C1-6 alkylene group; R″ is the residue of a diol or polyol; from 1-4 Rn are present; each Rn is independently selected from: H, C1-6 alkyl, C1-6 alkoxy, benzyloxy, halogen, —CHO, —CO2H, and —NO2, and each Rn is independently attached directly to aromatic ring or attached through a —(CH2)1-4— linker; each X independently is selected from:
—CH2COO— (glycolic acid moiety);—CH(CH3)COO— (lactic acid moiety);—CH2CH2OCH2COO— (dioxanone moiety);—CH2CH2CH2CH2CH2COO— (caprolactone moiety);—(CH2)yCOO— where y is selected from 2, 3, 4, and 6-24; and—(CH2CH2O)zCH2COO— where z is selected from 2-24; each X′ independently is selected from:
—OCH2CO— (glycolic acid moiety);—OCH(CH3)CO— (lactic acid moiety);—OCH2CH2OCH2CO— (dioxanone moiety);—OCH2CH2CH2CH2CH2CO— (caprolactone moiety); and,—O(CH2)yCO— where y is selected from 2, 3, 4, and 6-24;—O(CH2CH2O)zCH2CO— where z is selected from 2-24; each p is independently selected from 0, 1, 2, 3, 4, 5, and 6; and, each p′ is independently selected from 0, 1, 2, 3, 4, 5, and 6; provided that p+p′ total from 0 to 12.