Soluble Mediator

摘要

The present disclosure relates to the use of a soluble CD52 glycoprotein in treating diseases regulated by effector T-cells, for example sepsis or multiple sclerosis. The present disclosure also relates to diagnostic methods based on the detection of CD52 expression levels in a subject.

主权项

1. A method of treating or preventing sepsis or multiple sclerosis in a subject, the method comprising administering a therapeutically effective amount of any one or more of:
i) a soluble CD52 glycoprotein, ii) a fusion protein comprising soluble CD52 glycoprotein as a first protein, and a second protein; iii) a polynucleotide encoding the peptide portion of soluble CD52 glycoprotein of part i) or the fusion protein of part ii); iv) a vector comprising the polynucleotide of part iii); v) an isolated cell comprising the polynucleotide of part iii) or the vector of part iv); vi) an isolated CD52hi cell capable of producing soluble CD52 glycoprotein; vii) an isolated cell population comprising a plurality of CD52hi cells capable of producing soluble CD52 glycoprotein; viii) cell culture medium, or a fraction thereof comprising soluble CD52 glycoprotein, isolated from a cell culture comprising the cell of part vi) or the cell population of part vii); ix) an agent capable of increasing the level of expression of soluble CD52 glycoprotein by a cell; and x) a pharmaceutical composition comprising any one or more of i) to ix) and a pharmaceutically acceptable carrier,to the subject.