csPCNA Isoform Antibodies And Uses Thereof

摘要

Antibodies specifically bind only to a cancer specific proliferating cell nuclear antigen (csPCNA) isoform and not to the non-malignant proliferating cell nuclear antigen (nmPCNA) isoform. Methods and compositions to detect the presence of csPCNA isoform are disclosed.

主权项

1. A method for reducing tumor progression in a subject, comprising:
administering a pharmaceutically acceptable composition comprising a formulation of a therapeutically effective amount of cancer specific proliferating cell nuclear antigen (csPCNA) isoform-specific antibody that specifically binds cancer specific proliferating cell nuclear antigen (csPCNA) isoform, wherein the antibody does not bind to non-malignant proliferating cell nuclear antigen (nmPCNA), and wherein the antibody binds to an epitope of csPCNA comprising an amino acid sequence selected from LGIPEQEY (SEQ ID NO: 1), QLGIPEQEY (SEQ ID NO: 9), LGIPEQEYSCVV (SEQ ID NO: 13), LGIPEQEYSCV (SEQ ID NO: 14), and LGIPEQEYSC (SEQ ID NO: 15); and a delivery component to an individual having a tumor.