METHODS FOR PRODUCING RECOMBINANT GLYCOPROTEINS WITH MODIFIED GLYCOSYLATION

摘要

Genetically engineered host animal cells capable of producing glycoproteins having modified glycosylation patterns, e.g., defucosylation and/or monoglycosylation. Such host animal cells can be engineered to express fucosidase, endoglycosidase or both.

主权项

1. A genetically engineered host animal cell, which expresses a fucosidase, an endoglycosidase, or both, wherein the engineered host animal cell produces glycoproteins having modified glysocylation.