GIP-BASED MIXED AGONISTS FOR TREATMENT OF METABOLIC DISORDERS AND OBESITY

摘要

PROBLEM TO BE SOLVED: To provide glucagon peptides that exhibit GIP agonist activity in addition to glucagon and/or GLP-I activity.SOLUTION: An analog of glucagon having GIP agonist activity exhibits at least 1% activity of native GIP activity at the GIP receptor, where an amino acid modification at a specific position confers the GIP agonist activity. Also provided are pharmaceutical compositions comprising such glucagon peptides and therapeutic methods of using such peptides.