发明名称 |
HEPATITIS C VIRUS PARTICLES FORMATION PROMOTER, AND METHOD OF PRODUCING HEPATITIS C VIRUS PARTICLES |
摘要 |
A HCV particle formation promoter is capable of promoting formation of HCV particles in culture cells, and a method enhances production of HCV particles. A method evaluates an anti-HCV agent candidate substance, and a method produces a HCV vaccine. The HCV particle formation promoter includes as an active ingredient a statin or a pharmaceutically acceptable salt thereof. Addition of the statin or pharmaceutically acceptable salt thereof to HCV-infected culture cells can promote formation of infectious HCV particles and enhance production of the particles. In addition, an anti-HCV agent candidate substance is evaluated by culturing HCV-infected cells in the presence of the HCV particle formation promoter and the anti-HCV agent candidate substance. Further, a HCV vaccine is produced by using HCV particles produced by the method of enhancing production of HCV particles. |
申请公布号 |
US2015258189(A1) |
申请公布日期 |
2015.09.17 |
申请号 |
US201314432076 |
申请日期 |
2013.09.27 |
申请人 |
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ;TORAY INDUSTRIES, INC. ;TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE ;UNIVERSITY OF INDONESIA ;INDONESIAN INSTITUTE OF SCIENCES (LIPI) |
发明人 |
Hotta Hak;Aoki Chie;Wakita Takaji;Pratiwi Soedarmono;Ratna Sitompul;Lukman Hakim;Leonardus Kardono |
分类号 |
A61K39/29;C12N7/00;G01N33/50;C07D309/10 |
主分类号 |
A61K39/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Kobe JP |