RAPID FORMATION OF CHITOSAN SPONGES USING GUANOSINE 5'-DIPHOSPHATE: INJECTABLE SCAFFOLDS FOR TISSUE REGENERATION AND DRUG DELIVERY

摘要

It is disclosed Guanosine 5′-Diphosphate (GDP) crosslinked chitosan sponge or gelling composition which is used as a scaffold for tissue regeneration applications such as neural, cardiac, cartilage and bone regeneration. In addition, the sponge acts as a drug delivery system to provide local controlled drug release, such as delivering anti-cancer drugs locally at the tumor site.

主权项

1. A gelling composition comprising:
a) chitosan; and b) Guanosine 5′-Diphosphate (GDP),wherein the composition forms a gel when the chitosan is mixed with the GDP at a pH range from 5 to 6.