PARTICLES, METHODS AND USES THEREOF

摘要

The present disclosure, among other things, provides a composition including a nanoscale core; a plurality of capping agent entities associated on the core; an outer encapsulant layer; and a plurality of dopant entities distributed at locations selected from the group consisting of: on or within the nanoscale core, on or between capping agent entities, on or within the encapsulating layer, and combinations thereof. Provided technologies can achieve unprecedented levels of dopant entity density and/or surface localization, which, for a SE(R)RS-active agent dopant, results in dramatically improved signal intensity and/or imaging sensitivity.

主权项

1. A composition comprising:
a nanoscale core; a plurality of capping agent entities associated on the core; an outer encapsulant layer; and a plurality of SE(R)RS-active agent dopant entities distributed at locations selected from the group consisting of: on or within the nanoscale core, on or between capping agent entities, on or within the encapsulating layer, and combinations thereof, wherein the composition is characterized in that when embedded in 1% agarose in well-plates and imaged, the composition has a detection threshold of or below 20 fM for Raman imaging.