Bendamustine Solid Dispersions And Continuous Infusion

摘要

Provided herein are pharmaceutical compositions comprising nitrogen mustard, for example bendamustine hydrochloride, solid dispersions substantially free of degradants. Also provided are methods of producing and administering nitrogen mustards and in particular bendamustine hydrochloride solid dispersions substantially free of degradants. The pharmaceutical compositions can be used for any disease that is sensitive to treatment with bendamustine hydrochloride, such as neoplastic diseases.

主权项

1. A solid dispersion composition comprising
a. a solid form of one or more excipients; and b. one or more solid forms of crystalline bendamustine hydrochloride and amorphous bendamustine hydrochloride, and combinations thereof, wherein said solid dispersion is a spray-dried solid dispersion, or fluidized bed spray-dried solid dispersion that is substantially free of HP1, relative to bendamustine.