| 主权项 |
1. A method of treating a pathological condition associated with EP2 or EP4 receptors, the method comprising administering to a subject in need thereof a therapeutically effective amount of at least one compound having the structure:or a pharmaceutically acceptable salt thereof, wherein:
Ar is aryl, heteroaryl, substituted aryl, or substituted heteroaryl, wherein substituents are selected from alkyl, alkenyl, alkynyl, hydroxyalkyl, hydroxyl, alkoxy, halogen, —CN, —CF3, —C(O)R′, —C(O)OR′, —C(O)CF3, —SO2N(R1)2, —SO2NH2, or —NO2; L is C1-C6 alkylene; A is arylene or heteroarylene; E is —CO2R1, —CH2OR1, —C(O)N(R1)2, or tetrazol-5-yl; each R1 is independently H, C1-C6 alkyl, phenyl, or biphenyl; and n is 0 or 1. |
