| 主权项 |
1. A compound of formula (I): or its salts or pharmaceutically acceptable derivatives thereof; wherein: X1 is selected from a group consisting of CH2, C(═O), C(═NH), and NHC(═O); R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R2 is selected from the group consisting of optionally substituted alkyl, optionally substituted aryl, heteroaryl, and NR24R25; R3 is selected from the group consisting of hydrogen, halogen, hydroxy, alkoxy, aryloxy, optionally substituted alkyl, optionally substituted amino, optionally substituted amino sulfonyl, and nitrile; R4 is selected from the group consisting of optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroaryl; R5 is selected from the group consisting of hydrogen and optionally substituted alkyl; R24 and R25 are the same or different and each represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; m=1, 2 or 3; with the proviso that when X1 is C═O and R5 is H then R4 is not: wherein R10a is H or C1-6alkyl; and R11a is C1-6alkyl or aryl-C1-6alkyl. |
