| 摘要 |
The present invention relates to a use of fermented Camellia japonica seed oil which is high in the content of free essential fatty acids, and more specifically, to a medicine, a dietary supplement or a cosmetic product for preventing and alleviating benign prostatic hypertrophy and male-pattern baldness, containing fermented Camellia japonica seed oil as an active ingredient since the fermented Camellia japonica seed oil, which is prepared by fermenting Camellia japonica seed oil, is rich in free essential fatty acids and has remarkable 5-α reductase inhibitory activity, thereby preventing and alleviating benign prostatic hypertrophy and male-pattern baldness. According to the present invention, the effects of essential fatty acids can be maximized by increasing the content of essential fatty acids, which are isolated so as to facilitate absorption and in vivo utilization, through the indirect fermentation of Camellia japonica seed oil. In addition, according to the present invention, the fermented Camellia japonica seed oil has a similar activity to finasteride, which prevents and alleviates benign prostatic hypertrophy and male-pattern baldness by having little toxicity as a result of a single-dose toxicity test and cytotoxicity check, having an effect of lowering dihydrotestosterone by inhibiting 5-α reductase, exhibiting an effect of restoring the size of the prostate to a normal level with respect to benign prostatic hypertrophy, promoting the growth of hair follicle cells and exhibiting an effect of alleviating baldness phenomenon of examinees as a result of simple clinical trials, and thus can be applied, prepared, and sold as a cosmetic product, a dietary supplement or a pharmaceutical composition by using a fermented natural oil including fermented Camellia japonica seed oil having identical or similar efficacy and effects to natural product-derived one. |
