发明名称 |
Tricyclic PI3k inhibitor compounds and methods of use |
摘要 |
Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti- inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described. |
申请公布号 |
AU2011343712(B2) |
申请公布日期 |
2015.09.17 |
申请号 |
AU20110343712 |
申请日期 |
2011.12.15 |
申请人 |
F. HOFFMAN-LA ROCHE AG |
发明人 |
DOTSON, JENNAFER;HEALD, ROBERT ANDREW;HEFFRON, TIMOTHY;JONES, GRAHAM ELGIN;KRINTEL, SUSSIE LERCHE;MCLEAN, NEVILLE JAMES;NDUBAKU, CHUDI;OLIVERO, ALAN G.;SALPHATI, LAURENT;WANG, LAN;WEI, BINQING |
分类号 |
C07D487/14;A61K31/519;A61P35/00;C07D491/14;C07D495/14;C07D498/14 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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