发明名称 Ketamine Derivatives
摘要 The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).
申请公布号 US2015259277(A1) 申请公布日期 2015.09.17
申请号 US201314433957 申请日期 2013.10.08
申请人 SLEIGH James Wallace;DENNY William Alexander;JOSE Jiney;GAMAGE Swarnalatha Akuratiya;HARVEY Martyn Gregory;VOSS Logan James;AUCKLAND UNISERVICES LIMITED 发明人 Sleigh James Wallace;Denny William Alexander;Jose Jiney;Gamage Swarnalatha Akuratiya;Harvey Martyn Gregory;Voss Logan James
分类号 C07C229/46 主分类号 C07C229/46
代理机构 代理人
主权项 1. A compound of formula (I): wherein Y1 is —C2-6aliphaticC(O)OR1, —C2-6aliphaticOC(O)R1, —C1-6aliphaticC(O)OC1-6aliphaticC(O)OR1, or —C1-6aliphaticC(O)OC1-6aliphaticOR3, wherein each aliphatic is optionally substituted with one or more R2; R1 is C1-6aliphatic, optionally substituted with one or more halo, CN, NO2, NH2, NHR11, NR11R12, C1-6haloalkyl, C1-6haloalkoxy, C(O)NH2, C(O)NHR11, C(O)NR11R12, SO2R11, OR11, C(O)R11, and C1-6aliphatic; R2 is C1-6aliphatic, optionally substituted with one or more halo, OR11, or CN; R3 is hydrogen or R1; R11 and R12 are each independently C1-6aliphatic; or R11 and R12 together with the nitrogen atom to which they are attached are a heteroaryl or heterocyclyl ring; Y2 is hydrogen or R2; X1 and X2 are each independently hydrogen, R2, halo, NO2, NH2, NHR11, NR11R12, C1-6haloalkyl, C1-6haloalkoxy, C(O)NH2, C(O)NHR11, C(O)NR11R12, SO2R11, OR11, C(O)R11, C1-6aliphaticY1, OY1, C(O)Y1, SO2Y1, or C(O)NHY1 at any of the available 2-5 positions; or a pharmaceutically acceptable salt or solvate thereof.
地址 Hamilton NZ