发明名称 |
COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES |
摘要 |
<p>This invention provides a method for preparing a 1,2,3-triazole compound comprising contacting an organic azide with a 2-substituted-1-haloalkyne, in the presence of a copper catalyst and a copper-coordinating ligand (preferably a tertiary amine) in a liquid reaction medium, thereby forming a 1,4,5-substituted-1,2,3-triazole compound including a halo substituent at the 5-position of the triazole, the organic portion of the organic azide at the 1-position of the triazole, and the substituent of the 1-iodoalkyne at the 4-position of the triazole. A method for preparing 1-iodoalkynes is also provided.</p> |
申请公布号 |
EP2464635(B1) |
申请公布日期 |
2015.09.16 |
申请号 |
EP20100808679 |
申请日期 |
2010.08.11 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
HEIN, JASON E.;TRIPP, JONATHAN C.;KRASNOVA, LARISSA;SHARPLESS, K. BARRY;FOKIN, VALERY V. |
分类号 |
C07D249/04;B01J23/72;C07D405/04 |
主分类号 |
C07D249/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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