发明名称 |
RESTORING PHOSPHORYLATION OF A NOVEL PINK1 SUBSTRATE TO TREAT PARKINSON'S DISEASE |
摘要 |
The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm. |
申请公布号 |
EP2917342(A1) |
申请公布日期 |
2015.09.16 |
申请号 |
EP20130792867 |
申请日期 |
2013.11.07 |
申请人 |
VIB VZW;KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R&D |
发明人 |
DE STROOPER, BART;VERSTREKEN, PATRIK;MORAIS EPIFÂNIO, VANESSA |
分类号 |
C12N9/02 |
主分类号 |
C12N9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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