摘要 |
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced &bgr;-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses. |
申请人 |
PFIZER INC. |
发明人 |
COE, JOTHAM, WADSWORTH;ALLEN, JOHN, ARTHUR;DAVOREN, JENNIFER, ELIZABETH;DOUNAY, AMY, BETH;EFREMOV, IVAN, VIKTOROVICH;GRAY, DAVID, LAWRENCE, FIRMAN;GUILMETTE, EDWARD, RAYMOND;HARRIS, ANTHONY, RICHARD;HELAL, CHRISTOPHER, JOHN;HENDERSON, JACLYN, LOUISE;MENTE, SCOT, RICHARD;NASON, DEANE, MILFORD, II;O'NEIL, STEVEN, VICTOR;SUBRAMANYAM, CHAKRAPANI;XU, WENJIAN |