发明名称 |
COATED PREPARATION |
摘要 |
The present invention provides a preparation containing pioglitazone or a salt thereof as an active ingredient, which shows high bioavailability of pioglitazone and less interindividual variation in blood drug concentration, as well as a preparation with suppressed color change during preservation. The preparation contains a core containing a pharmaceutically acceptable organic acid with water solubility at 20°C of not less than 10 mg/mL and pK a1 (a negative common logarithm of the first acid dissociation constant K a1 ) at 25°C of not more than 5, and a coating layer containing pioglitazone or a salt thereof. The coating layer may further contain mannitol or trehalose. |
申请公布号 |
EP2172200(B1) |
申请公布日期 |
2015.09.16 |
申请号 |
EP20080791071 |
申请日期 |
2008.07.10 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
BANDO, HIROTO;OMACHI, YOSHIHIRO;KIYOSHIMA, KENICHIRO |
分类号 |
A61K31/4439;A61K9/16;A61K9/20;A61K9/48;A61K9/50 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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