A radiation analysis system/method that automatically optimizes the efficiency calibration of a counting system based on benchmark data and variable parameters associated with radiation source/sensor/environment (RSSE) combinations is disclosed. The system/method bifurcates RSSE context (SSEC) model parameters into WELL-KNOWN (fixed) parameters (WNP) and NOT-WELL-KNOWN (variable) parameters (NWP) The NWP have associated lower/upper limit values (LULV) and a shape distribution (LUSD) describing NWP characteristics. SSEC models are evaluated using randomized statistical NWP variations or by using smart routines that perform a focused search within the LULV /LUSD to generate model calibration values (MCV) and calibration uncertainty values (UCV) describing the overall SSEC efficiencies.
