| 摘要 |
<p>An immunogenic composition comprising: (a) polymer microparticles comprising a biodegradable polymer; (b) an antigen adsorbed to the microparticles, said antigen selected from one or more of (i) toxoid antigen selected from tetanus toxoid and diphtheria toxoid and (ii) a polysaccharide-containing antigen selected from Hib polysaccharide antigen, a Hib conjugate antigen comprising polysaccharide and polypeptide regions, a meningococcal polysaccharide antigen, a meningococcal conjugate antigen comprising polysaccharide and polypeptide regions, a pneumococcal polysaccharide antigen, and a pneumococcal conjugate antigen comprising polysaccharide and polypeptide regions; and (c) a pharmaceutically acceptable excipient, and further comprising an additional polypeptide-containing antigen, an additional polysaccharide- containing antigen, an additional conjugate antigen, or an additional polynucleotide-containing antigen, adsorbed to the surface of the microparticles. Alternatively the additional polypeptide-containing antigen, polysaccharide- containing antigen, conjugate antigen or polynucleotide-containing antigen can be entrapped within the microparticles.</p> |
