Compositions and methods for treating organ dysfunction

摘要

A method of retarding cellular senescence comprising (i) providing an extracellular matrix (ECM) composition comprising ECM from an adolescent tissue source, the ECM comprising an exogenously added cytokine, and (ii) administering ECM composition to an organ with cells exhibiting cellular senescence, wherein, the cytokine interacts with at least one molecule in the ECM composition and modulates ROS production of the cells, whereby, the cellular senescence is abated.

主权项

1. A composition for treating organ dysfunction, comprising:
an extracellular matrix (ECM) composition comprising ECM from a mammalian tissue source comprising small intestine submucosa, said ECM comprising endogenous proteoglycans, transforming growth factors-β (TGF-β), fibroblast growth factors-2 (FGF-2) and vascular endothelial growth factor (VEGF), said ECM further comprising an exogenously added cytokine, said cytokine comprising at least 0.1% by weight of said composition, said cytokine being linked to said ECM, wherein, when said composition is administered to biological tissue, said cytokine interacts with at least one molecule in said ECM composition, wherein said ECM composition modulates ROS production and, thereby, telomere activity.